Catecholamines increase nerve growth factor mRNA content in both mouse astroglial cells and fibroblast cells

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Catecholamines induce an increase in nerve growth factor content in the medium of mouse L-M cells.

L-M cells, a mouse fibroblast cell line, synthesized and secreted a nerve growth factor (NGF). The neurite outgrowth stimulatory activity, immunoreactivity, molecular weight, and isoelectric point of L-M cell NGF were identical to those of beta-NGF of the mouse submaxillary gland. Treatment of the cells with either norepinephrine or epinephrine in the range of 0.05-0.2 mM for 24 h resulted in a...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 1989

ISSN: 0014-5793

DOI: 10.1016/0014-5793(89)81391-2